As networks expand in size, complexity, and importance, operators and researchers confront a new set of challenges: scaling infrastructure efficiently, guaranteeing high availability and robustness, ensuring end-to-end security, and maintaining the agility to adapt to rapid changes. At the same time, the correctness and consistency of configurations have never been more critical. This networking channel session brings together network operators to explore the latest challenges in large-scale network operations, and the innovative solutions being developed to address them. We focus on how automation and AI-driven approaches are transforming network management, from predictive maintenance and anomaly detection to dynamic resource allocation and self-healing architectures. The discussions will also cover network evolution management and the rapid, reliable deployment of new services, ensuring that networks remain future-proof and responsive to emerging demands.